prevention of malaria in africa


Authors: Josh Hanson, Sue J. Lee, Md Amir Hossain, Nicholas M. Anstey, Prakaykaew Charunwatthana, Richard J. Maude, Hugh W. F. Kingston, Saroj K. Mishra, Sanjib Mohanty, Katherine Plewes, Kim Piera, Mahtab U. Hassan, Aniruddha Ghose, M. Abul Faiz, Nicholas J. Insecticide-treated nets are the cornerstone of malaria prevention efforts in Africa.

Authors: Nicholas M Douglas, Gysje J Pontororing, Daniel A Lampah, Tsin W Yeo, Enny Kenangalem, Jeanne Rini Poespoprodjo, Anna P Ralph, Michael J Bangs, Paulus Sugiarto, Nicholas M Anstey and Ric N Price, Citation: =�T &U���ur�Wᢹ<>%�. This pilot project promoted prevention of malaria at household level using an integrated approach in two rural communities in Wakiso District, Uganda. Prevention of malaria is currently based on two complementary methods: chemoprophylaxis and protection against mosquito bites. The findings of this study reaffirm the WHO recommendation of universal LLIN coverage for all populations at risk of malaria. The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. 12:134.

2015 2014 On 16 November 2016, WHO released the findings of a 5-year evaluation conducted in 340 locations across 5 countries: Benin, Cameroon, India, Kenya and Sudan. Malaria is present in over 100 countries worldwide, including large areas of South America, Africa and Southeast Asia, and it is estimated that over 40% of the world’s population is at risk of infection.

0000005143 00000 n In Uganda, malaria is the leading cause of morbidity and mortality especially among children under five years of age. 0000004216 00000 n

2015 14:70. 2015 0000032240 00000 n !T��CB�^�ͮE��(�#*y{Mr��К#�)n?����� The global agenda for malaria has, once again, embraced the possibility of eradication. Understanding the mechanisms of naturally-acquired malaria immunity is essential to inform vaccine design; many studies are currently underway to explore these immunological mechanisms and identify promising vaccine candidates. Terms and Conditions, 13:125, The Microvascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease’s pathogenesis and outcome are unknown. BMC Medicine Simple genetic changes that correlate with drug resistance are used routinely to identify resistant pathogens. 2015 0000005769 00000 n Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. 2016 Achieving adequate antimalarial drug exposure is essential for curing malaria. There are still substantial gaps in the coverage of core malaria control tools. Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. BMC Medicine Recent clinical evidence discredits the long-held notion of this infection as intrinsically benig... Citation: BMC Medicine Eliminating malaria in at least 10 countries is a milestone for 2020. BMC Medicine 0000029024 00000 n Fe... Citation: 13:170. Over 90% of the world’s severe and fatal Plasmodium falciparum malaria is estimated to affect young children in sub-Sahara Africa, where it remains a common cause of hospital admission and inpatient mortality. 2015 These “molecular markers” have usually been defined long after the phenotype of resistance was not... Citation:
BMC Medicine 0000030168 00000 n In addition to the human burden of malaria, the economic burden is vast. The hunt for protective correlates of immunity to, A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine, Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review, Implications of the licensure of a partially efficacious malaria vaccine on evaluating second-generation vaccines, Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data.

Malaria remains an acute public health problem, particularly in sub-Saharan Africa. Intermittent preventive treatment in pregnancy has not been evaluated outside of Africa. 2015 As history has shown, there will be no single magic bullet that can be applied to every epidemiological setting. If global targets are to be met, funding from both domestic and international sources must increase substantially. 13:294. The study by Gonçalves and colleagues provides valuable new data on how the addition of low-dose primaq... Citation: BMC Medicine Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths.

BMC Medicine BMC Medicine Authors: Faith HA Osier, Gaoqian Feng, Michelle J Boyle, Christine Langer, Jingling Zhou, Jack S Richards, Fiona J McCallum, Linda Reiling, Anthony Jaworowski, Robin F Anders, Kevin Marsh and James G Beeson, Citation:

�����=׶�s��=�?��9οS�ۖlyj��J���o��_��+�vM��w>��k���{��[z 13:290. 0000029256 00000 n Primaquine plus artemisinin combination therapy for reduction of malaria transmission: promise and risk, Randomized trial of primaquine hypnozoitocidal efficacy when administered with artemisinin-combined blood schizontocides for radical cure of, Parasite clearance after malaria therapy: staying a step ahead of drug resistance, Artemether-lumefantrine treatment of uncomplicated, Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data, Tolerability and safety of weekly primaquine against relapse of, Antimalarial drugs for preventing malaria during pregnancy and the risk of low birth weight: a systematic review and meta-analysis of randomized and quasi-randomized trials, The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation models, Malaria eradication and elimination: views on how to translate a vision into reality, Malaria mapping: understanding the global endemicity of falciparum and vivax malaria, Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study, Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study, Prescriber and patient-oriented behavioural interventions to improve use of malaria rapid diagnostic tests in Tanzania: facility-based cluster randomised trial, Maximizing antimalarial efficacy and the importance of dosing strategies, The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis, Observing in real time the evolution of artemisinin resistance in, The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data, Management of severe paediatric malaria in resource-limited settings, Global malaria eradication and the importance of, Sulphadoxine-pyrimethamine plus azithromycin for the prevention of low birthweight in Papua New Guinea: a randomised controlled trial. Artesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. BMC Medicine The report found that more than half (53%) of the population at risk in sub-Saharan Africa slept under a treated net in 2015, compared to 30% in 2010. BMC Medicine

0000029579 00000 n Authors: Joachim Schmutzhard, Peter Lackner, Raimund Helbok, Helene Verena Hurth, Fabian Cedric Aregger, Veronika Muigg, Josua Kegele, Sebastian Bunk, Lukas Oberhammer, Natalie Fischer, Leyla Pinggera, Allan Otieno, Bernards Ogutu, Tsiri Agbenyega, Daniel Ansong, Ayola A. Adegnika…, Citation:

Malaria caused by Plasmodium vivax threatens over 2 billion people globally and sickens tens of millions annually. Malaria has a significant impact on the health of infants, young children, and pregnant women worldwide. 13:118. statement and
BMC Medicine 2015 Vaccinations will begin 2018. BMC Medicine 13:110. Privacy To protect women in areas of moderate and high malaria transmission in Africa, WHO recommends "intermittent preventive treatment in pregnancy" (IPTp) with sulfadoxine-pyrimethamine. Guidelines for the diagnosis, treatment and prevention of malaria in pregnancy have been developed as a companion document to this framework.

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0000003603 00000 n Authors: Melissa A Penny, Katya Galactionova, Michael Tarantino, Marcel Tanner and Thomas A Smith, Citation: White, Nicholas P. J. Day…, Citation: WHO, At the 2015 World Health Assembly, Member States adopted the, Coronavirus disease outbreak (COVID-2019), Coronavirus disease outbreak (COVID-19) », Malaria control improves for vulnerable in Africa, but global progress off-track. The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Controversy surrounds the precise numbers of malaria deaths and clinical episodes in Africa. While several malaria vaccines are …

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